5-Amino-1MQ: A Research Reference Guide to the NNMT Inhibitor
By Lemon Labs Research Desk · Updated July 1, 2026
In short
5-Amino-1MQ is a small molecule studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular methylation and NAD+ salvage metabolism. In preclinical research it is investigated for effects on adipocyte metabolism. It is a research-use-only reference compound.
What is 5-Amino-1MQ?
5-Amino-1MQ is a small-molecule compound studied as an inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT methylates nicotinamide, a reaction that sits at the intersection of cellular methylation balance and the NAD+ salvage pathway. Because of that position, NNMT is a frequent target in metabolic-enzyme research.
Mechanism studied in the literature
In preclinical and in-vitro studies, inhibiting NNMT with compounds like 5-Amino-1MQ has been examined for downstream effects on cellular NAD+ and methyl-donor pools, and on adipocyte (fat cell) energy metabolism. This is mechanistic enzyme research; it does not establish any human outcome.
Why NNMT inhibition draws interest
NNMT activity links two heavily studied systems — methylation and NAD+ metabolism (see our NAD+ guide). That makes selective NNMT inhibitors useful research tools for probing how those pathways interact in metabolic models.
Handling and quality
Supplied as a lyophilized powder; store cold, sealed, and protected from light, and reconstitute in the lab. Verify identity and ≥99% purity on the lot-specific Certificate of Analysis.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What does 5-Amino-1MQ inhibit?
It is studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme involved in methylation balance and NAD+ salvage metabolism.
Is 5-Amino-1MQ a peptide?
No — it is a small molecule, not a peptide, though it is studied alongside metabolic research compounds. It is supplied for research use only.
Is it approved for human use?
No. It is a research-use-only reference compound for laboratory work, not for human or veterinary use.