Cagrilintide: A Research Reference Guide to the Long-Acting Amylin Analog
By Lemon Labs Research Desk · Updated June 29, 2026
In short
Cagrilintide is a synthetic, long-acting analog of amylin — a peptide hormone co-secreted with insulin. In research it is studied as an agonist of amylin and calcitonin receptors, and it is frequently investigated in combination with GLP-1 agonists like semaglutide. It is a research-use-only reference compound.
What is cagrilintide?
Cagrilintide is a synthetic analog of amylin, a hormone normally co-secreted with insulin from pancreatic beta cells. It is engineered for an extended half-life, making it a long-acting amylin analog studied in metabolic research alongside the incretin peptide family.
Receptor activity studied in research
Amylin signals through a family of receptors formed by the calcitonin receptor combined with receptor-activity-modifying proteins (RAMPs). Cagrilintide is studied as an agonist across amylin and calcitonin receptors. A notable theme in the literature is its pairing with GLP-1 agonists such as semaglutide, where researchers examine how amylin-pathway and incretin-pathway agonism combine.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Verify ≥99% HPLC purity and mass-spec identity on the lot COA.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What is cagrilintide?
Cagrilintide is a long-acting synthetic analog of amylin, a hormone co-secreted with insulin. It is studied as an agonist of amylin and calcitonin receptors.
Why is cagrilintide studied with semaglutide?
Researchers study the combination of amylin-pathway agonism (cagrilintide) with GLP-1 agonism (semaglutide) to examine how the two distinct mechanisms interact in metabolic models.
Is cagrilintide for human use?
No. Material sold here is a research-use-only reference compound, not for human or veterinary use.