GHK-Cu: A Research Reference Guide to the Copper Tripeptide
By Lemon Labs Research Desk · Updated June 29, 2026
In short
GHK-Cu is a copper-binding tripeptide (glycyl-L-histidyl-L-lysine complexed with copper(II)) that occurs naturally in human plasma. In research it is studied for copper transport, extracellular-matrix remodeling, and broad effects on gene expression. It is a research-use-only reference compound.
A naturally occurring copper complex
GHK is a tripeptide — glycine, histidine, lysine — that binds copper(II) ions with high affinity to form GHK-Cu. It is found naturally in human plasma at concentrations that decline with age, which is part of why it has attracted research attention.
What research describes
In-vitro and preclinical studies have examined GHK-Cu as a copper carrier and as a modulator of extracellular-matrix proteins. Gene-expression profiling research has reported that GHK can influence the expression of a large number of genes, prompting interest in it as a signaling molecule rather than a simple nutrient. These findings are from laboratory models.
Handling and quality
Supplied lyophilized, often as a blue-tinted powder reflecting the copper complex; store cold, sealed, and protected from light. Verify identity and ≥99% purity on the lot COA.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What is GHK-Cu?
GHK-Cu is the copper(II) complex of the tripeptide glycyl-L-histidyl-L-lysine, a molecule that occurs naturally in human plasma and is studied in research for matrix remodeling and gene-expression effects.
Why is GHK-Cu blue?
The blue tint comes from the bound copper(II) ion in the GHK-copper complex.
Is GHK-Cu for human use?
No. It is supplied as a research-use-only reference compound for laboratory work, not for human or veterinary use.