Kisspeptin: A Research Reference Guide to the Reproductive Neuropeptide
By Lemon Labs Research Desk · Updated July 17, 2026
In short
Kisspeptin is a neuropeptide encoded by the KISS1 gene that signals through the GPR54 (KISS1R) receptor. In research it is a key regulator of the reproductive endocrine axis, studied for its role in triggering gonadotropin-releasing hormone (GnRH) signaling. It is a research-use-only reference compound.
What is kisspeptin?
Kisspeptin is a neuropeptide product of the KISS1 gene. It binds the G-protein-coupled receptor GPR54 (also called KISS1R). In reproductive-endocrinology research, the kisspeptin–GPR54 system is studied as an upstream regulator of the hypothalamic–pituitary–gonadal (HPG) axis.
Mechanism studied in research
Preclinical work describes kisspeptin signaling as a trigger for gonadotropin-releasing hormone (GnRH) neurons, which in turn govern downstream reproductive hormone signaling. This makes kisspeptin a frequently-used probe in neuroendocrine research models.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Verify identity and ≥99% purity on the lot Certificate of Analysis.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What receptor does kisspeptin act on?
It signals through GPR54 (KISS1R), a G-protein-coupled receptor central to reproductive-endocrinology research.
What is kisspeptin studied for?
In preclinical research it is studied as an upstream regulator of the reproductive (HPG) axis, triggering GnRH neuron signaling.
Is kisspeptin for human use?
No. It is a research-use-only reference compound, not for human or veterinary use.