Melanotan II (MT-2): A Research Reference Guide to the Melanocortin Agonist
By Lemon Labs Research Desk · Updated July 15, 2026
In short
Melanotan II (MT-2) is a synthetic cyclic peptide analog of α-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective agonist of melanocortin receptors. In research it is studied for melanocortin-receptor signaling, including pathways involved in melanogenesis (pigment production). It is a research-use-only reference compound.
What is Melanotan II?
Melanotan II is a synthetic, cyclic analog of α-MSH. Unlike the KPV fragment (which isolates α-MSH’s anti-inflammatory arm), Melanotan II is a broad melanocortin-receptor agonist, engaging several receptors in the melanocortin family, and is more stable than native α-MSH.
Mechanism studied in research
In preclinical and in-vitro studies, Melanotan II is examined for activation of melanocortin receptors and the downstream signaling involved in melanogenesis. As a non-selective agonist it is a research tool for probing melanocortin-pathway biology generally.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Verify identity and ≥99% purity on the lot Certificate of Analysis.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What receptors does Melanotan II target?
It is a non-selective agonist of melanocortin receptors, studied for the signaling those receptors drive — including melanogenesis pathways.
How does it relate to KPV?
Both derive from α-MSH biology, but KPV is a tripeptide fragment studied for anti-inflammatory signaling, while Melanotan II is a broad melanocortin-receptor agonist.
Is Melanotan II for human use?
No. It is a research-use-only reference compound, not for human or veterinary use.