KPV: A Research Reference Guide to the Anti-Inflammatory Tripeptide
By Lemon Labs Research Desk · Updated June 29, 2026
In short
KPV (lysine-proline-valine) is a tripeptide corresponding to the C-terminal fragment of α-melanocyte-stimulating hormone (α-MSH). In preclinical research it is studied for anti-inflammatory activity, including reported modulation of NF-κB signaling, without the pigmentary effects of the full α-MSH molecule. It is a research-use-only reference compound.
What is KPV?
KPV is a short tripeptide made of lysine, proline, and valine. It represents the C-terminal tripeptide of α-MSH, a melanocortin peptide. Researchers are interested in KPV because studies suggest it retains anti-inflammatory properties associated with α-MSH while lacking the receptor activity responsible for pigmentation.
Mechanisms studied in research
Preclinical and in-vitro studies have examined KPV in the context of inflammatory signaling, with reports describing reduced pro-inflammatory cytokine activity and modulation of the NF-κB pathway. Some research has investigated KPV in gastrointestinal inflammation models, including its uptake by intestinal epithelial cells via peptide transporters. These findings are confined to laboratory research.
Why the C-terminal fragment is studied separately
Full-length α-MSH engages melanocortin receptors tied to pigmentation. KPV is studied as a way to probe the anti-inflammatory arm of melanocortin biology in isolation. That selectivity is the reason it appears in research distinct from melanotan-type peptides.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Verify ≥99% HPLC purity and mass-spec identity on the lot-specific COA.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What is KPV derived from?
KPV is the C-terminal tripeptide (lysine-proline-valine) of α-melanocyte-stimulating hormone (α-MSH). It is studied for the anti-inflammatory properties associated with α-MSH.
What is KPV studied for?
In preclinical and in-vitro research, KPV is studied for anti-inflammatory signaling, including modulation of the NF-κB pathway and effects in gastrointestinal inflammation models.
Is KPV for human use?
No. KPV is a research-use-only reference compound for laboratory work, not for human or veterinary use.