MOTS-c: A Research Reference Guide to the Mitochondrial-Derived Peptide
By Lemon Labs Research Desk · Updated June 29, 2026
In short
MOTS-c (mitochondrial open reading frame of the twelve S rRNA type-c) is a short peptide encoded within mitochondrial DNA. In research it is studied as a regulator of metabolic homeostasis, with reported involvement in AMPK signaling. It is a research-use-only reference compound.
A peptide encoded by mitochondrial DNA
MOTS-c is one of a small class of mitochondrial-derived peptides — short peptides encoded within the mitochondrial genome rather than the nuclear genome. This unusual origin is part of why it is studied as a signaling molecule linking mitochondria to broader cellular metabolism.
What research describes
Preclinical studies have examined MOTS-c in the context of metabolic regulation and the AMP-activated protein kinase (AMPK) pathway, a central energy-sensing system in cells. It has also been studied for nuclear translocation under metabolic stress in cell models. These observations are from laboratory research.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Confirm ≥99% purity by HPLC and identity by mass spectrometry on the lot COA.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What is unusual about MOTS-c?
MOTS-c is a mitochondrial-derived peptide — it is encoded within mitochondrial DNA rather than the nuclear genome, which is why it is studied as a mitochondria-to-cell signaling molecule.
What pathway is MOTS-c associated with?
In research models, MOTS-c has been associated with the AMPK energy-sensing pathway and metabolic regulation.
Is MOTS-c approved for human use?
No. It is a research-use-only reference compound for laboratory work, not for human or veterinary use.