SS-31 (Elamipretide): A Research Reference Guide to the Mitochondrial Peptide
By Lemon Labs Research Desk · Updated July 22, 2026
In short
SS-31 (also known as elamipretide) is a synthetic mitochondria-targeted tetrapeptide studied for its binding to cardiolipin, a phospholipid of the inner mitochondrial membrane. In research it is investigated for effects on mitochondrial membrane stability and bioenergetics. It is a research-use-only reference compound.
What is SS-31?
SS-31 is a synthetic tetrapeptide engineered to concentrate in mitochondria. Its defining feature in research is selective binding to cardiolipin, a phospholipid found almost exclusively in the inner mitochondrial membrane where it supports the structure of the electron-transport chain.
Mechanism studied in research
By associating with cardiolipin, SS-31 is studied in preclinical models for its effects on inner-membrane organization, electron-transport-chain efficiency, and reactive-oxygen-species handling. This places it within the same mitochondrial-biology research area as MOTS-c and NAD+.
Handling and quality
Supplied lyophilized; store cold, sealed, and protected from light, and reconstitute in the lab. Verify identity and ≥99% purity on the lot Certificate of Analysis.
Research-use-only statement
This compound is supplied strictly for in-vitro research and laboratory use. It is not a drug, supplement, food, or cosmetic, has not been evaluated by the FDA, and is not intended to diagnose, treat, cure, or prevent any disease. It is not for human or veterinary use. All information here summarizes published scientific literature for educational purposes for qualified researchers — it is not medical advice and does not describe human administration.
Reference compounds mentioned
Frequently asked
What does SS-31 target?
It is a mitochondria-targeted peptide studied for its selective binding to cardiolipin in the inner mitochondrial membrane.
Is SS-31 the same as elamipretide?
SS-31 is the research designation for the peptide also known as elamipretide. Material here is supplied for research use only.
Is SS-31 for human use?
No. It is a research-use-only reference compound, not for human or veterinary use.